AMIODARONE

AMIODARONE

AMIODARONE
Class
	Anti-arrythmic
Action
	Prolongs QT interval.
Indications
	Recurrent Ventricular Fibrillation. Recurrent Hemodynamically unstable ventricular tachycardia.
Contraindications
	Hypersensitivity. Sinus Bradycardia. Sino-Atrial Heart Blocks. Thyroid dysfunction. Pregnancy and breast feeding
Precaution
	Do not administer with other drugs that prolong QT interval. Terminal elimination is extremely long up to 40 days. With multiple dosing, cumulative doses>2.2g/24 hours are associated with significant hypotension clinical trials.
Side effects
	Nausea and Vomiting. Hepatotoxicity. Phototoxicity. Thyroid dysfuctions.
Administration
Rout: IV	Onset: 1-2 minutes	Peak effect: 10 minutes	Duration: Variable
Adult Dose:
	Stable Wide-QRS Tachycardia First dose 150 mg IV/IO push diluted in 20-30 ml D5W over 10 minutes. Repeat dose 150mgIV if VT recurs Cardiac Arrest First dose : 300mg IV/IO Push Repeat dose :150mg IV/IO Push
Pediatric Dose:
	Stable Wide-QRS Tachycardia First dose: 5mg/kg IV/IO over 20 minutes (Max 150mg) May repeat once if needed Cardiac Arrest 5mg/kg IV/IO bolus may repeat up to 2 times for refractory VF/Pulseless VT