DOPAMINE HYDROCHLORIDE

DOPAMINE HYDROCHLORIDE

DOPAMINE HYDROCHLORIDE
Class
	Sympathomimetic.
Action
	At low doses (less than 2 ug/kg/min). Dilates renal and mesenteric blood vessels. Venoconstricts. Arterial resistance varies. At moderate doses (2 - 6 ug/kg/min):Beta 1 stimulating effect on the heart increasing cardiac output. At high doses (6-10 ug/kg/min). Alpha 1 effects. Peripheral vasoconstriction including renal and mesenteric vessels. Increases left and right ventricular preload. Doses greater than or equal to 10 ug/kg/min. Alpha 1 stimulating effects may reverse mesenteric and renal artery dilatation resulting in decreased blood flow. Increased preload due to effects on venous system.
Indications
	Cardiogenic shock. Hypovolemia shock with sufficient fluid resuscitation. Septic shock. Anaphylactic shock.
Contraindications
	Hypovolemia without aggressive fluid replacement. Pre-existing tachydysrhythmias. Pheochromocytoma (adrenal tumor which causes excessive release of epinephrine and norepinephrine).
Precaution
	Should not be administered in the presence of severe tachyarrhythmias. Should not be administered in the presence of ventricular fibrillation. Ventricular irritability.
Side effects

Administration
Rout: IV/IO	Onset: Immediate	Peak effect: 5-10 minutes	Duration: During infusion
Adult Dose:
	For IV/IO Infusion Only. In general, infusion rate is adjusted to the blood pressure and clinical response. Administer 2-20 ug/kg/min IV/IO drip Titrate to obtain SBP> 90mmHg Initial infusion rate 5-10 ug/kg/min.
Pediatric Dose:
	For IV Infusion Only. In general, infusion rate is adjusted to the blood pressure and clinical response. Administer 2-20 ug/kg/min IV/IO drip Titrate to obtain SBP> 70+( 2 x age in yrs) Initial infusion rate 2 ug/kg/min.