MAGNESIUM SULFATE

MAGNESIUM SULFATE

MAGNESIUM SULFATE
Class
	Class V Antidysrhythmic, Electrolyte.
Action
	Replaces and maintains magnesium levels. Interferes with the release of acetylcholine at the myoneural junction.
Indications
	Severe refractory ventricular fibrillation. Seizures due to eclampsia. Torsades de pointes. Severe bronchoconstriction with impending respiratory failure. Hypomagnesemia.
Contraindications
	Patients with heart block or recent myocardial infarction.
Precaution
	Caution should be used when magnesium is administered to safeguard against clinically significant hypotension or asystole.
Side effects
	Hypotension. Circulatory collapse. Cardiac and respiratory depression.
Administration
Rout: IV	Onset: Immediate	Peak effect: Variable	Duration: 1 hour
Adult Dose:
	Cradiac arrest: 2 g slow IV (diluted in 10 mL D5W) over 5-20 minutes Torsade de Pointes: 2 g slow IV (diluted in 50-100 mL D5W) over 5-60 minutes Eclampsia: 4g mgso4 to 20% solution IV over 4 minutes
Pediatric Dose:
	Torsades de Pointes: 50 mg/kg IV/IO repeat every 5 minutes to Max 2 gms