MIDAZOLAM

MIDAZOLAM
Class
 
  • Sedative, Benzodiazepine.
  • Hypnotic.
Action
 
  • A short acting benzodiazepine with strong hypnotic and amnestic properties.
Indications
 
  • Pre-sedation of responsive patients prior to administration of a neuromuscular blocking agents.
  • Sedation of intubated patients with ventilatory difficulty secondary to bucking or combativeness.
Contraindications
 
  • Hypotension.
  • Known hypersensitivity.
  • Respiratory depression
  • Head injuries
Precaution
  • The effects of Midazolam can be accentuated by CNS depressants, such as narcotics and alcohol.
Side effects
  • Respiratory depression.
  • Apnea.
  • Hypotension.
  • Amnesia.
Administration
Rout: IV/IO Onset: Immediate Peak effect: 3-5 minutes Duration: < 2 hours
Rout: IM Onset: 15 minutes Peak effect: 30-60 minutes Duration: 1-6 hours
Adult Dose:
Agitated Patient:
  • 2.0 -5 mg slow IV/IO or IM repeat every 5 minutes as needed the desired effect.
Sedation:
  • 2.0 -5 mg slow IV/IO/ IM repeat every 5 minutes as needed
Seizures:
  • 5 mg IV/IO/IM repeat every 5 minutes as needed
Pediatric Dose:
Sedation:
  • 0.2mg/kg IV/IO. OR 0.1-0.15mg/kg IV/IO titrate, repeat after 2-3 minutes after evaluating the full sedative effect
Seizures
  • 0.1 mg/kg slow IV/IO/IM repeat every 5 minutes as needed (Maximum 10mg)
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